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External validation across independent centres remains the most reliable test of generalizability in ART, where protocol drift and centre effects are common [459, 470, 471]

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Individual patient factors The effect of smoking and sex on olanzapine plasma concentrations following OLAI dosing in the HGKA study showed a trend consistent with historical oral olanzapine data in which the range of olanzapine concentrations is known to be shifted toward a higher but overlapping distribution of values in nonsmokers than in smokers and in women than in men